نوع مقاله : علمی - پژوهشی
نویسندگان
shahid beheshti university کدپستی:
چکیده
کلیدواژهها
عنوان مقاله [English]
Sirt3 is a member of the sirtuin family of protein deacetylases that is localized in mitochondria and regulates mitochondrial function. The aim of this study was to investigate the effect of eight-weeks aerobic continuous and high intensity interval training on levels of Sirt3 in wistar rat’s skeletal muscle tissue. Methods: 24 vistar rats were randomly divided into six groups consisted of: 1) Obese- High-intensity interval training, 2) Obese- Continues training 3) Obese control and 4) Non-Obese control. In the whole period of study, were given a high fat diet to groups of rat 1, 2 and 3. After familiarization, CT and HIIT rats performed aerobic continuous training and high intensity interval training three times a week for eight weeks, respectively. 48 hours after the last training session, the mice were sacrificed. Results: Western blotting study showed that the amount of SIRT3 protein of Soleus muscle in HIIT and CT groups was higher than OB and Cont. group significantly (p< 0/05). Also, The SIRT3 content was higher in HIIT group than in CT group, but not significant. Also, no significant difference was observed between the SIRT3 content of OB and Cont.. However, the SIRT3 content was lower in OB group. Conclusion: It seems that Using HIIT exercise can be effective as continuous training on muscle mitochondrial function and ultimately contribute to longevity, especially in obese patients and raises important factors such as SIRT3.
کلیدواژهها [English]