اثر هشت هفته تمرین هوازی متوسط بر فشار خون، سطوح سرمی نیتریک اکساید و آپلین زنان میانسال مبتلا به پیش فشار خونی

نوع مقاله : علمی - پژوهشی

نویسندگان

1 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، کرمانشاه، ایران

2 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران

چکیده

هدف: فشار خون یکی از عوامل ایجاد بیماری های قلبی  عروقی می باشد که سلامت افراد جامعه را تحت تأثیر قرار
می دهد. هدف از این مقاله، بررسی اثر 8 هفته تمرین هوازی متوسط بر فشار خون، نیتریک اکساید و آپلین در زنان مبتلا
به پیش پرفشاری خون است.
روش ها: بیست و چهار زن 30 تا 45 ساله مبتلاء به پیش پرفشاری خون )فشار 139 روی 89 (، به طور تصادفی به دو
گروه هوازی و کنترل تقسیم شدند. تمرین هوازی سه جلسه در هفته بود. به طوری که در هفته اول، آزمودنی ها به مدت
30 دقیقه با 50 درصد ضربان قلب ذخیره دویدند و با گذشت زمان، با افزایش شدت تمرین در هفته هشتم، مدت تمرین
45 دقیقه و شدت آن به 55 درصد رسید. اندازه گیری فشار خون و نمونه گیری خون، یک روز پیش از نخستین مرحله و
48 ساعت پس از آخرین مرحله تمرین انجام شد. سطوح سرمی آپلین و نیتریک اکساید با استفاده از کیت های تجاری، به
روش الایزا اندازه گیری شدند. تجزیه و تحلیل آماری داده ها با استفاده از آزمون تی مستقل و وابسته در سطح معناداری
p>0/05 صورت گرفت.
نتایج: پس از 8 هفته فعالیت هوازی، سطوح سرمی آپلین و نیتریک اکساید در گروه تمرین افزایش معناداری داشتند، در
صورتی که فشار خون کاهش معناداری داشت ) 05 / .)P≥0
نتیجه گیری: به نظر می رسد، 8 هفته تمرین هوازی متوسط، می تواند با افزایش سطوح سرمی نیتریک اکساید و آپلین
باعث کاهش فشار خون زنان میانسال مبتلا به پیش پرفشاری خون شود.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of eight weeks aerobic training on nitric oxide and apelin levels in women with pre-hypertension

نویسندگان [English]

  • leila hojatoleslami 1
  • vahid tadibi 2
  • naser behpoor 2
1 Faculty of Physical Education and Sport Sciences, Islamic Azad University, Kermanshah, Iran
2 2Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran
چکیده [English]

Purpose: Blood pressure is one of the causes of cardiovascular disease that affects people’s health. The aim of this study was to investigate the effect of eight weeks of moderate aerobic training on blood pressure, nitric oxide and apelin in women with pre-hypertension.
Methods: Twenty-four women aged 30-45 years with pre-hypertension (Pressure 139 over 89) were randomly divided in two groups: aerobic and control. Aerobic exercise was three sessions per week. In the first week, the subjects performed a 50% heart rate reserve (HRR) for 30 minutes, and with increasing training intensity in the eighth week, the training lasted 45 minutes and the severity reached 55%. Blood pressure measurement and blood sampling were performed one day before the first and 48 hours after the last exercise. Serum levels of apelin and nitric oxide were measured using commercial kits by ELISA method. Statistical analysis of data was performed using independent and dependent t-test at a significant level p <0.05.
Results: After 8 weeks of aerobic activity, Serum levels of apelin and nitric oxide increased significantly in the training group (p <0.05). If the blood pressure level decreased significantly (p <0.05).
Conclusion: It seems that 8 weeks of aerobic exercise can reduce blood pressure by increasing Serum levels of nitric oxide and apelin in middle-aged women with pre-hypertension.

کلیدواژه‌ها [English]

  • Prehypertension
  • Aerobic exercise
  • Nitric oxide
  • Apelin
  • Endothelial function
1. Ahmadi A, Hasanzadeh J, Rajaeifard A. To
determine the relative factors on Hypertension
in Kohrang, Chaharmahal & Bakhtiari
province. Iranian Journal of Epidemiolgy.
2008;4(2):19-25 [In Persian].
2. Collier S. Sex Differences in the Effects of Aerobic
and Anaerobic Exercise on Blood Pressure
and Arterial Stiffness. Gend Med 2008:115-23.
3. Denise L, fernhall B. Advance cardiovascular
exercise physiology: Human kinetics; 2011.p.
91-210.
4. Erdogan D, Yildirim I, Ciftci O. Effects of normal
blood pressure, prehypertension and on
hypertension coronary microvascular function.
Circulation. 2007;115:593-9.
5. Inaba Y, Chen JA, Bergmann SR. Prediction of
future cardiovascular outcomes by flow-mediated
vasodilatation of brachial artery. Int J Cardiovasc
Imaging. 2010;26(6):631-40.
6. Ferro C, Webb D. Endothelial dysfunction
and hypertension. Drugs. 1997;1:30-41.
7. Higashi Y, Yoshizumi M. Exercise and endothelial
function: Role of endothelium-derived
nitric oxide and oxidative stress in healthy
subjects and hypertensive patients. Pharmacol
Ther. 2004;102:87-96.
8.Tatemoto K, Takayama K, ZouPeptide
Apelin Lowers Blood Pressure Via a Nitric
Oxide-Dependent Mechanism. Regul Pept.
2001;99(2-3):87-92.
9. Aiyagari Venkatesh G. Hypertension: the
most importantpreventable risk factor for cerebrovascular
disease. The Lancet Neurology.
2011;10(7):606 - 7.
10. Tatemoto K, Hosoya M, Habata Y, Fujii R,
Kakegawa T, Zou M, et al. Isolation and characterization
of a novel endogenous peptide
ligand for the human APJ receptor. Biochemical
and biophysical research communications.
1998;251(2):471-6.
11. Heinonen M, Purhonen A, Miettinen P,
Paakkonen M, Pirinen E, Alhava B, et al. Apelin,
orexin-A and leptin plasma levels in morbid
obesity and effect of gastric banding. Regul
Pept. 2005;130(1-2):7-13.
12. Kalea A, Batlle D. Apelin and ACE2 in cardiovascular
disease. Curr Opin Investig Drugs.
2010;11(3):273-82.
13. Meral C, Tascilar E, Karademir F, Tanju I,
Dogru T. Elevated plasma levels of apelin in
children with type 1 diabetes mellitus. Journal
of Pediatric Endocrinology and Metabolism.
2010;23(5):497-502.
14. Boucher J, Masri B, Daviaud D, Gesta S,
Guigné C, Mazzucotelli A, et al. Apelin, a newly
identified adipokine up regulated by insulin
and obesity. Endocrinology. 2005;146(4):1764-
71.
15.Kleinz M, Skepper J, Davenport A. Immunocytochemical
Localisation of the Apelin Receptor,
APJ, to Human Cardiomyocytes, Vascular Smooth Muscle and Endothelial Cells. Regul
Pept. 2005;126(3):233-40.
16.Lauglin N, Woodman W. Interval Sprint
Training Enhanced Endothelial Function
and eNOS in Some Arteries That Perfuse
White Gasterocemius Muscle. J Appl Physiol.
2004;66(1):233-44.
17.Bauer V, Sotníková R. Nitric oxide-the endothelium-
derived relaxing factor and its role
in endothelial functions. General physiology
and biophysics. 2010;29(4):319-40.
18.Maxwell AJ, Schauble E, Bernstein D,
Cooke JP. Limb blood flow during exercise
is dependent on nitric oxide. Circulation.
1998;98(4):369-74.
19.Green D, Maiorana A, Driscoll G, Taylor R.
Effect of exercise training on endothelium-derived
nitric oxide function in humans. J Physiol.
2004;561(1):1-25.
20.Joyner M, Dietz N. Nitric oxide and vasodilation
in human limbs. J Appl Physiol.
1997;83(6):1785-96.
21. Lakatta E, Levy D. Arterial and cardiac aging
major shareholders in cardiovascular disease
enterprises: A»set up» for vascular disease.
Circulation. 2003;107:146-39.
22.zimmer A, Teixeira R, bonetto J, etal a. Effects
of aerobic exercise training on metabolism
of nitric oxide and endothelin-1 in lung
parenchyma of rats with pulmonary arterial
hypertension. mol cell biochem. 2017;429(1-
2):73-89.
23. Farahati S, Attarzadeh Hosseini S, Bigeh N,
Mahjob O. The Effect of Aerobic Exercise on Nitric
Oxide Plasma Levels and Postmenopausal
Women›s Endothelium Function. Razi Journal
of Medical Sciences. 2013;20:115 [In Persian].
24. Ghardashi Afooei A, Ghaeni A, Gholami
Broujeni B. The Effect of Aerobic Exercise on
Plasma Levels of Nitric Oxide, Vascular Endothelial
Cell Function and Secondary Outcome
in Patients with Type 2 Diabetes. Journal
of Nursing Rehabilitation. 1395;2(3):27-39 [In
Persian].
25.Tofighi A, Babaei S, Separate and Combined
Effects of Aerobic Exercise and Grain Supplementation
on Plasma Levels of Apelin and Glucose
in Type 2 Diabetic Rats. Urmia Medical
Journal. 2016;24(1):10-18 [In Persian].
26.Souri, Asad Mir, Yari M., Rastegar M., Mansouri
M, The Effect of Eight-Week Aerobic
Training on Apelin-13 and Insulin Resistance in
Overweight Men. Journal of Yasuj University of
Medical Sciences. 2017;22(3):122 [In Persian].
27. Shabani Nia M, Shahidi F, Rajabi H, Nazari
A. The Effect of 12-Week Periodic Training on
Blood Pressure and Stroke Concentration in
Middle-Aged Men with Hypertension. Journal
of Isfahan Medical School. 2017;35(425):368-
75 [In Persian].
28.Niaparast W, Naeemi S, Akbarzadeh Baghban
A. The effects of a continuous and discontinuous
aerobic exercise session on peripheral
blood pressure in a young and healthy young
population. Journal of Rehabilitation Sciences.
2016;5(3):103-95 [In Persian].
29. Uncle Ali N, Daryanoush F, Babaei Beigi M,
Mohammadi M. The Effect of 12-Week Aerobic Exercise on Serum Levels of Cardiotropin 1,
Left Ventricular Hypertrophy and Hypertension
in Elderly Women with Hypertension. University
of Medical Sciences and Services Health
Care in Zanjan Province. 2016;24(106):9-1 [In
Persian].
30. Swain, David P. American College of Sports
Medicine. Philadelphia: ACSM›s guidelines for
exercise testing and prescription; 2014.p.693.
31.Pasler C, Luscher TF, Landmesser U. Molecular
mechanisms of vascular effects of high-density
lipoprotein: Alterations in cardiovascular
disease. Embo Mol Med. 2012;4(4):251-68.
32. Siasos S, Athanasiou D, Tousoulis D, Terzis
G, Stasinnaki A, Tourikis P, et al. Acute effects
of different types of aerobic exercise on vascular
function. J Am Coll Cardiol. 2014;63(12):16-
42.
33. Zaros P, Romero P, Bacci M, Moraes C, Zanesco
A. Effect of 6- months of physical exercise
on the nitrate/nitrite levels in hypertensive
postmenopausal women. Journal of BMC
Women Health. 2009;17(2):142-50.
34. Faselis C, Doumas M, Kokkinos JP. Exercise
capacity and progression from prehypertension
to hypertension. Hypertension.
2012;60:333-8.
  • تاریخ دریافت: 08 اردیبهشت 1397
  • تاریخ بازنگری: 19 بهمن 1399
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 تیر 1398