اثر هشت هفته تمرین مقاومتی بر سطوح BDNF و عملکرد حافظه زنان میانسال مبتلا به سندروم متابولیک

محسن ابراهیمی, پگاه میرزا علی, سید محسن آوندی

چکیده


مقدمه و هدف: هدف از تحقیق حاضر بررسی اثر هشت هفته تمرین مقاومتی بر سطوح BDNF و عملکرد حافظه زنان میانسال مبتلا به سندروم متابولیک بود. روش شناسی: 22 زن داوطلب میانسال مبتلا به سندروم متابولیک به صورت نمونه‌گیری در دسترس، گزینش شدند و به طور تصادفی به دو گروه تمرین (تعداد=12، 14/5 ± 08/43 سال، 16/7 ± 13/74 کیلوگرم) و گروه کنترل (تعداد=10، 53/4 ± 9/39 سال، 61/11 ± 23/82 کیلوگرم) تقسیم شدند. آزمودنی‌های گروه تمرین به مدت هشت هفته و سه روز در هر هفته به تمرین مقاومتی پرداختند. تمرین شامل سه نوبت هشت تا ده تکراری (75% -80% 1RM) با در نظر گرفتن اصل اضافه بار بود. در مراحل پیش‌ازمون و پایان تمرین، آزمون‌های عملکرد حافظه کوتاه‌مدت و میان­مدت و بلندمدت و همچنین خون­گیری انجام شد. داده‌ها با استفاده از آزمون‌های تی مستقل، تی وابسته و آنالیز واریانس با اندازه‌گیری مکرر 2×2 با سطح معنی داری 05/0 P≤تجزیه و تحلیل شدند. یافته‌ها: تغییر معنی‌داری در سطوح BDNF و حافظه میان مدت در دو گروه تمرین و کنترل مشاهده نشد (05/0P≥). نتایج آزمون  tوابسته افزایش معنی‌داری در گروه تمرین در حافظه کوتاه‌مدت و بلندمدت نشان داد (05/0P≤)، اما پس از بررسی اثر تعاملی تمرین تغییرات معنی‌داری مشاهده نشد(05/0P≥). نتیجه گیری: با وجود اینکه BDNF به عنوان یک متابوتروفین، میانجی اثرات ورزش بر عملکرد شناختی شناخته شده است؛ اما هشت هفته تمرین مقاومتی نمی‌تواند اثر مطلوبی بر افزایش BDNF و عملکرد حافظه در زنان میانسال مبتلا به سندروم متابولیک داشته باشد. 

واژگان کلیدی


تمرین مقاومتی، BDNF، عملکرد حافظه- زنان میانسال- سندروم متابولیک

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منابع و مآخذ مقاله


Allan, R., et al. (2013). "Exercise and Bdnf Production as a Future Treatment for Alzheimer’s Disease."

Okosun IS, Annor F, Esuneh F, Okoegwale EE.

(2013) Metabolic syndrome and impaired healthrelated

quality of life and in non-Hispanic White,

non-Hispanic Blacks and Mexican-American

Adults. Diabetes & Metabolic Syndrome:

Clinical Research & Reviews.7(3):154-60.

Raffaitin C, Gin H, Empana J-P, Helmer C, Berr

C, Tzourio C, et al.(2009). Metabolic Syndrome

and Risk for Incident Alzheimer's Disease or

Vascular Dementia The Three-City Study.

Diabetes care.32(1):169-74.

Baker LD, Cross DJ, Minoshima S, Belongia D,

Watson GS, Craft S. (2011) Insulin resistance

and Alzheimer-like reductions in regional

cerebral glucose metabolism for cognitively

normal adults with prediabetes or early type 2

diabetes. Archives of neurology.68(1):51-7.

Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi

K, Matsui Y, et al. (2010). Insulin resistance is

associated with the pathology of Alzheimer disease

The Hisayama Study. Neurology.75(9):764-70.

Schrijvers EM, Witteman J, Sijbrands E, Hofman

A, Koudstaal P, Breteler M.( 2010). Insulin

metabolism and the risk of Alzheimer disease

The Rotterdam Study. Neurology.75(22):1982-7.

Dik MG, Jonker C, Comijs HC, Deeg DJ, Kok

A, Yaffe K, et al. (2007) Contribution of

metabolic syndrome components to cognition in

older individuals. Diabetes care.30(10):2655-60.

Yaffe K. (2007) Metabolic syndrome and

cognitive disorders: is the sum greater than its

parts? Alzheimer Disease & Associated

Disorders.21(2):167-71.

Xu B, Goulding EH, Zang K, Cepoi D, Cone

RD, Jones KR, et al. (2003) Brain-derived

neurotrophic factor regulates energy balance

downstream of melanocortin-4 receptor. Nature

neuroscience. 6(7):736-42.

Nonomura T, Tsuchida A, Ono-Kishino M,

Nakagawa T, Taiji M, Noguchia H. (2001)

Brain-derived neurotrophic factor regulates

energy expenditure through the central nervous

system in obese diabetic mice. Experimental

Diabetes Research.2(3):201-9.

Tsuchida A, Nonomura T, Nakagawa T, Itakura

Y, Ono‐Kishino M, Yamanaka M, et al. (2002)

Brain‐derived neurotrophic factor ameliorates

lipid metabolism in diabetic mice. Diabetes,

Obesity and Metabolism. 4(4):262-9.

Correia PR, Scorza FA, da Silva SG, Pansani A,

Toscano-Silva M, de Almeida AC, et al. (2011)

Increased basal plasma brain-derived neurotrophic

factor levels in sprint runners. Neuroscience

bulletin. 27(5):325-9.

Yamada K, Nabeshima T. (2003) Brain-derived

neurotrophic factor/TrkB signaling in memory

processes. Journal of pharmacological sciences.

(4):267-70.

Benraiss A, Chmielnicki E, Lerner K, Roh D,

Goldman SA. (2001) Adenoviral brain-derived

neurotrophic factor induces both neostriatal and

olfactory neuronal recruitment from endogenous

progenitor cells in the adult forebrain. The

Journal of Neuroscience. 21(17):6718-31.

Zuccato C, Cattaneo E. (2009) Brain-derived

ابراهیمی و همکاران

neurotrophic factor in neurodegenerative

diseases. Nature Reviews Neurology.5(6):311-

Noble EE, Billington CJ, Kotz CM, Wang C.

(2011) The lighter side of BDNF. American

Journal of Physiology-Regulatory, Integrative

and Comparative Physiology. 300(5):R1053-

R69.

Knaepen K, Goekint M, Heyman EM, Meeusen

R. (2010) Neuroplasticity - exercise-induced

response of peripheral brain-derived

neurotrophic factor: a systematic review of

experimental studies in human subjects. Sports

medicine (Auckland, NZ). 40(9):765-801.

Lommatzsch M, Zingler D, Schuhbaeck K,

Schloetcke K, Zingler C, Schuff-Werner P, et al.

(2005) The impact of age, weight and gender on

BDNF levels in human platelets and plasma.

Neurobiology of aging.26(1):115-23.

Allan R, Collino T, Oluwarounke H. (2013)

Exercise and Bdnf Production as a Future

Treatment for Alzheimer’s Disease.

Goekint M, Heyman E, Roelands B, Njemini R,

Bautmans I, Mets T, et al. (2008). No influence

of noradrenaline manipulation on acute exerciseinduced

increase of brain-derived neurotrophic

factor. Med Sci Sports Exerc.40(11):1990-6.

Zoladz J, Pilc A, Majerczak J, Grandys M,

Zapart-Bukowska J, Duda K. (2008) Endurance

training increases plasma brain-derived

neurotrophic factor concentration in young

healthy men. J Physiol Pharmacol. 59(Suppl

:119-32.

Vega SR, Strüder HK, Wahrmann BV, Schmidt

A, Bloch W, Hollmann W. (2006) Acute BDNF

and cortisol response to low intensity exercise

and following ramp incremental exercise to

exhaustion in humans. Brain research.

(1):59-65.

Ferris LT, Williams JS, Shen C-L. (2007) The

effect of acute exercise on serum brain-derived

neurotrophic factor levels and cognitive function.

Medicine and science in sports and

exercise.39(4):728-34.

Tang SW, Chu E, Hui T, Helmeste D, Law C.(

. Influence of exercise on serum brainderived

neurotrophic factor concentrations in

healthy human subjects. Neuroscience letters.

(1):62-5.

Rasmussen P, Brassard P, Adser H, Pedersen

MV, Leick L, Hart E, et al. (2009) Evidence for a

release of brain‐derived neurotrophic factor from

the brain during exercise. Experimental

physiology. 94(10):1062-9.

Winter B, Breitenstein C, Mooren FC, Voelker

K, Fobker M, Lechtermann A, et al. (2007) High

impact running improves learning. Neurobiology

of learning and memory. 87(4):597-609.

Yarrow JF, White LJ, McCoy SC, Borst SE.

(2010). Training augments resistance exercise

induced elevation of circulating brain derived

neurotrophic factor (BDNF). Neuroscience

letters. 479(2):161-5.

Schiffer T, Schulte S, Hollmann W, Bloch W,

Struder HK. (2009). Effects of strength and

endurance training on brain-derived neurotrophic

factor and insulin-like growth factor 1 in

humans. Hormone and metabolic research =

Hormon- und Stoffwechselforschung =

Hormones et metabolisme. 41(3):250-4.

Schulz KH, Gold SM, Witte J, Bartsch K, Lang

UE, Hellweg R, et al. (2004). Impact of aerobic

training on immune-endocrine parameters,

neurotrophic factors, quality of life and

coordinative function in multiple sclerosis.

Journal of the neurological sciences. 225(1-

:11-8.

Castellano V, White LJ. (2008). Serum brainderived

neurotrophic factor response to aerobic

exercise in multiple sclerosis. Journal of the

neurological sciences.269(1):85-91.

Correia PR, Pansani A, Machado F, Andrade M,

Silva AC, Scorza FA, et al. (2010). Acute

strength exercise and the involvement of small or

large muscle mass on plasma brain-derived

neurotrophic factor levels. Clinics (Sao Paulo,

Brazil). 65(11):1123-6.

Goekint M, De Pauw K, Roelands B, Njemini R,

Bautmans I, Mets T, et al. (2010) Strength

training does not influence serum brain-derived

neurotrophic factor. European journal of applied

physiology. 110(2):285-93.

Cao L, Lin E-JD, Cahill MC, Wang C, Liu X,

During MJ. (2009). Molecular therapy of obesity

and diabetes by a physiological autoregulatory

approach. Nature medicine. 15(4):447-54.

Wilson RS, Schneider JA, Bienias JL, Evans

DA, Bennett DA. (2003). Parkinsonianlike signs

and risk of incident Alzheimer disease in older

persons. Archives of neurology. 60(4):539-44.

Smith PJ, Blumenthal JA, Hoffman BM, Cooper

H, Strauman TA, Welsh-Bohmer K, et al.( 2010).

Aerobic exercise and neurocognitive performance:

a meta-analytic review of randomized controlled

trials. Psychosomatic medicine. 72(3):239.

Raschetti R, Albanese E, Vanacore N, Maggini

M. (2007). Cholinesterase inhibitors in mild

cognitive impairment: a systematic review of

randomised trials. PLoS medicine. 4(11):e338.

Lachman ME, Neupert SD, Bertrand R, Jette

و عملکرد حافظه زنان میانسال ... 1323 BDNF اثر هشت هفته تمرین مقاومتی بر سطوح

AM. (2006). The effects of strength training on

memory in older adults. Journal of aging and

physical activity. 14(1):59-73.

Leff P, Romo H, Matus M, Hernández A, Calva

JC, Acevedo R, et al. (2002). Understanding the

neurobiological mechanisms of learning and

memory: memory systems of the brain, longterm

potentiation and synaptic plasticity. Part III

B. Salud Mental. 25(3):64-76.

Expert Panel on Detection E. (2001). Executive

summary of the third report of the National

Cholesterol Education Program (NCEP) expert

panel on Detection, Evaluation, and Treatment of

high blood cholesterol in adults (Adult Treatment

Panel III). Jama. 285(19):2486.

Brzycki M. (1993). Strength testing—predicting

a one-rep max from reps-to-fatigue. Journal of

Physical Education, Recreation & Dance.

(1):88-90.

Conceicao MS, Bonganha V, Vechin FC, de

Barros Berton RP, Lixandrão ME, Nogueira

FRD, et al. (2013). Sixteen weeks of resistance

training can decrease the risk of metabolic

syndrome in healthy postmenopausal women.

Clinical interventions in aging. 8:1221.

Stone MH, O'Bryant H, Garhammer J, McMillan

J, Rozenek R.( 1982). A Theoretical Model of

Strength Training. Strength & Conditioning

Journal. 4(4):36-9.

Brown LE, Weir JP.( 2001). Asep Procedures

Recommendation I: Accurate Assessment of

Muscular Strength and Power. Professionalization

of Exercise Physiology. 4(11).

Marnat G. (2005). Psychological Evaluation

Guidelines for clinical psychologists, counselors

and psychiatrists. Translation by Mohammad

Hassan Pasha Sharifi and Mohammad Reza

Nikkhou Tehran: Growth Publication(Persian).

Deschenes MR, Kraemer WJ. (2002).

Performance and physiologic adaptations to

resistance training. American Journal of Physical

Medicine & Rehabilitation. 81(11):S3-S16.

Levinger I, Goodman C, Matthews V, Hare DL,

Jerums G, Garnham A, et al. (2008). BDNF,

metabolic risk factors, and resistance training in

middle-aged individuals. Med Sci Sports Exerc.

(3):535-41.

Coelho F, Pereira D, Lustosa L, Silva J, Dias J,

Dias R, et al. (2012) Physical therapy intervention

(PTI) increases plasma brain-derived neurotrophic

factor (BDNF) levels in non-frail and pre-frail

elderly women. Archives of gerontology and

geriatrics. 54(3):415-20.

Matthews V, Åström M-B, Chan M, Bruce C,

Krabbe K, Prelovsek O, et al. (2009).Brainderived

neurotrophic factor is produced by

skeletal muscle cells in response to contraction

and enhances fat oxidation via activation of

AMP-activated protein kinase. Diabetologia.

(7):1409-18.

Parnow A, Karimi I, Hosseini SA. (2015). Effect

of Resistance Training on Plasma Brain Derived

Neurotrophic Factor Levels in Rats. Journal of

Knowledge & Health; VOL 10, NO 3:2015.

Babaei P, damirchi a, Azali Alamdari K. (2013).

Effects of Endurance Training and Detraining on

Serum BDNF and Memory Performance in

Middle Aged Males with Metabolic Syndrome.

Iranian Journal of Endocrinology and

Metabolism. 15(2):132-42.

Suwa M, Kishimoto H, Nofuji Y, Nakano H,

Sasaki H, Radak Z, et al. (2006). Serum brainderived

neurotrophic factor level is increased and

associated with obesity in newly diagnosed

female patients with type 2 diabetes mellitus.

Metabolism. 55(7):852-7.

Ramsbottom R, Currie J, Gilder M. (2010).

Relationships between components of physical

activity, cardiorespiratory fitness, cardiac

autonomic health, and brain-derived neurotrophic

factor. Journal of sports sciences. 28(8):843-9.

Golden E, Emiliano A, Maudsley S, Windham

BG, Carlson OD, Egan JM, et al. (2010).

Circulating brain-derived neurotrophic factor and

indices of metabolic and cardiovascular health:

data from the Baltimore Longitudinal Study of

Aging. PloS one. 5(4):e10099.

Arentoft A, Sweat V, Starr V, Oliver S,

Hassenstab J, Bruehl H, et al. (2009). Plasma

BDNF is reduced among middle-aged and

elderly women with impaired insulin function:

evidence of a compensatory mechanism. Brain

and cognition. 71(2):147-52.

Chang Y-K, Pan C-Y, Chen F-T, Tsai C-L,

Huang C-C. (2012). Effect of resistance exercise

training on cognitive function in healthy older

adults: a review. Journal of aging and physical

activity. 20(4):497-517.

Colcombe S, Kramer AF. (2003). Fitness effects

on the cognitive function of older adults a metaanalytic

study. Psychological science. 14(2):125-

Solfrizzi V, Scafato E, Capurso C, D’Introno A,

Colacicco AM, Frisardi V, et al. (2011).

Metabolic syndrome, mild cognitive impairment,

and progression to dementia. The Italian

Longitudinal Study on Aging. Neurobiology of

aging. 32(11):1932-41.

Komulainen P, Lakka TA, Kivipelto M, Hassinen

M, Helkala E-L, Haapala I, et al. (2007). Metabolic

ابراهیمی و همکاران

syndrome and cognitive function: a populationbased

follow-up study in elderly women. Dementia

and geriatric cognitive disorders. 23(1):29-34.

Yates KF, Sweat V, Yau PL, Turchiano MM,

Convit A. (2012). Impact of metabolic syndrome

on cognition and brain a selected review of the

literature. Arteriosclerosis, thrombosis, and

vascular biology. 32(9):2060-7.

Cassilhas RC, Viana VA, Grassmann V, Santos

RT, Santos RF, Tufik S, et al. (2007). The impact

of resistance exercise on the cognitive function

of the elderly. Medicine and science in sports

and exercise. 39(8):1401.

Tsutsumi T, Don BM, Zaichkowsky LD,

Delizonna LL. (1997). Physical fitness and

psychological benefits of strength training in

community dwelling older adults. Applied

human science. 16(6):257-66.

Kramer AF, Erickson KI. (2007). Capitalizing on

cortical plasticity: influence of physical activity

on cognition and brain function. Trends in

cognitive sciences. 11(8):342-8.

Cotman CW, Berchtold NC. (2002). Exercise: a

behavioral intervention to enhance brain health

and plasticity. Trends in neurosciences. 25(6):

-301.


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